ARNT and HEY1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARNT	HEY1
Description		aryl hydrocarbon receptor nuclear translocator	hes related family bHLH transcription factor with YRPW motif 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body Aryl Hydrocarbon Receptor Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Notch Signaling Involved In Heart Development Negative Regulation Of Biomineral Tissue Development Cellular Response To Glucocorticoid Stimulus Circulatory System Development Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis
Pathways		Regulation of gene expression by Hypoxia-inducible Factor PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Body mass index ( 26426971) Congenital left-sided heart lesions ( 26965164) Cutaneous squamous cell carcinoma ( 32041948) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Melanoma ( 21983785 28212542) Metabolic syndrome ( 31589552) Platelet count ( 32888494) Rhegmatogenous retinal detachment ( 23585552) Tea consumption ( 31046077) Urate levels ( 23263486)
Interacting Genes		77 interacting genes: ADH5 AHR AHRR AIP AKT1 ARL14 ARNT2 BECN1 BRCA1 CALCOCO1 CASP3 CASP9 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CSNK2A1 DIABLO EP300 EPAS1 EPHA2 ERBB2 ESR1 FGFR4 FZR1 GLIS1 GLIS2 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HGF HIF1A HIF3A HNF4A IRAK4 KPNA1 KPNA3 KPNA5 KPNA6 LATS2 LSM8 MAP2K5 MAPK14 MTA3 MYC NCOA1 NCOA2 NCOA7 NCOR2 NF2 NPAS4 PDGFRA PML PTGES3 RAF1 RELA SENP6 SIM1 SIM2 SMAD9 SP1 STK11 STRBP TACC3 TEAD2 TGM2 TNFAIP1 TP53 TRIP11 TUBB2A UBE2I	22 interacting genes: ARNT CREBZF DAZAP2 FBXW7 FOXH1 GATA1 HES1 HEY2 KRTAP6-2 LAPTM5 MDM2 MYOD1 NTRK3 PITX2 PLEKHB2 PRKD2 SKIL SMAD3 SMAD9 TENT5D TP53 YTHDF1
Entrez ID		405	23462
HPRD ID		00524	04260
Ensembl ID		ENSG00000143437	ENSG00000164683
Uniprot IDs		A8K6P0 B0AZM1 P27540 Q53F30	B4DEI9 Q9Y5J3
PDB IDs		1D7G 1X0O 2A24 2ARN 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J 4LPZ 4PKY 4XT2 5TBM 5UFP 5V0L 6CZW 6D09 6D0B 6D0C	2DB7
Enriched GO Terms of Interacting Partners?
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