LPP and VASP

Data Source:
HPRD (in vitro, in vivo)

		LPP	VASP
Description		LIM domain containing preferred translocation partner in lipoma	vasodilator stimulated phosphoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytosol Plasma Membrane Focal Adhesion	Cytosol Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Exosome
	Molecular Function	Protein Binding Metal Ion Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding
	Biological Process	Biological_process Cell-cell Adhesion	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Cell Junction Assembly Protein Homotetramerization
Pathways			Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) B cell non-Hodgkin lymphoma ( 23749188) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 27539887) Blood protein levels ( 29875488) Celiac disease ( 22057235 20190752 30572963 18311140) Chronic kidney disease ( 29124443) Chronic lymphocytic leukemia ( 28165464 26956414) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Cutaneous squamous cell carcinoma ( 27424798) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Early spontaneous preterm birth ( 31477735) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 29124443) Evening vs. morning chronotype (sMEQ score) ( 32579418) Follicular lymphoma ( 25279986) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Graves' disease ( 22922229) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Hodgkin's lymphoma ( 29196614) IgE levels ( 22075330) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 29785010 31959993 29235454) Itch intensity from mosquito bite ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494 27863252) Mortality in sepsis ( 27639821) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Nodular sclerosis Hodgkin lymphoma ( 29196614) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494) Renal function-related traits (BUN) ( 22797727) Response to platinum-based chemotherapy (cisplatin) ( 21844884) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549) Type 2 diabetes ( 24509480 30054458 30297969 25760438 28869590) Type 2 diabetes (young onset) and obesity ( 24465431) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 22951725 20410501 27723757) White matter integrity (bipolar disorder risk interaction) ( 23218918)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
Interacting Genes		7 interacting genes: ACTN1 ATP5MF ATRAID MTNR1A SCRIB SHPRH VASP	44 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP CDC42 CEP43 DMRTB1 DNMBP ENAH ERMAP EVL FAT1 FRS3 FYB1 GSN IQGAP1 LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX
Entrez ID		4026	7408
HPRD ID		02828	03415
Ensembl ID		ENSG00000145012	ENSG00000125753
Uniprot IDs		B7Z871 B7Z8W0 B7ZLW0 Q93052	A0A024R0V4 P50552
PDB IDs			1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?
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