LLGL1 and CD46

Data Source:
HPRD (two hybrid, in vitro)

		LLGL1	CD46
Description		LLGL scribble cell polarity complex component 1	CD46 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Cis Cisterna Cytoplasm Cytoskeleton Plasma Membrane Axon Cortical Actin Cytoskeleton Early Endosome Membrane Trans-Golgi Network Membrane	Inner Acrosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Extracellular Exosome
	Molecular Function	GTPase Activator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Myosin II Binding	Virus Receptor Activity Protein Binding Signaling Receptor Activity Cadherin Binding
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Axonogenesis Regulation Of Notch Signaling Pathway Cortical Actin Cytoskeleton Organization Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of GTPase Activity Regulation Of Protein Secretion Establishment Of Spindle Orientation Protein-containing Complex Assembly	Adaptive Immune Response T Cell Mediated Immunity Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Complement Activation Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Transforming Growth Factor Beta Production
Pathways			Regulation of Complement cascade
Drugs
Diseases
GWAS		LDL cholesterol ( 30275531)	Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Chronic central serous retinopathy ( 30073298) Drug experimentation measurement ( 30718321) Early age-related macular degeneration ( 32843070) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Heart rate ( 23583979) Immune response to measles vaccine (measles-specific neutralising antibody titre) ( 28289848) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Refractive error ( 32231278) Resting heart rate ( 29769521 27798624) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27841878 30578418) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: ACD AGTR1 CACNA1A CD46 STX4 USP11	14 interacting genes: AGR3 ANKRD46 C3 DLG4 GPR37L1 ITGB1 LLGL1 MGAT5B MSN POU4F2 SRC TSPAN4 VTI1B YES1
Entrez ID		3996	4179
HPRD ID		02982	00406
Ensembl ID		ENSG00000131899	ENSG00000117335
Uniprot IDs		Q15334	P15529
PDB IDs			1CKL 1HR4 2O39 3INB 3L89 3O8E 5FO8
Enriched GO Terms of Interacting Partners?
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