ARHGDIB and ANKRD1

Data Source:
BioGRID (two hybrid)

		ARHGDIB	ANKRD1
Description		Rho GDP dissociation inhibitor beta	ankyrin repeat domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Membrane Cytoplasmic Vesicle Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol I Band
	Molecular Function	GTPase Activity Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	RNA Polymerase II Transcription Factor Binding P53 Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding
	Biological Process	Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Multicellular Organism Development Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Redox State Negative Regulation Of Trophoblast Cell Migration Regulation Of Actin Cytoskeleton Reorganization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Regulation Of Lipid Metabolic Process Cellular Response To Drug Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Protein Kinase C Signaling Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Biosynthetic Process
Pathways		Rho GTPase cycle	PPARA activates gene expression
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 29617998) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: ANKRD1 APP CASP3 CDC42 EZR RAC1 RAC2 RAC3 RHOA RHOH UBE3A UFM1 VAV1	23 interacting genes: APPL1 ARHGDIB ASH2L CASQ2 CDCA7L DNAJB6 DST DYSF LRPPRC MAPRE3 MEOX2 MYBPC1 MYL1 MYOM2 MYPN NAGK REPS1 SPANXN2 TRIM55 TRIM63 TTN TULP3 ZNF446
Entrez ID		397	27063
HPRD ID		04162	10647
Ensembl ID		ENSG00000111348	ENSG00000148677
Uniprot IDs		A0A024RAS5 P52566	A0A384NYH5 Q15327
PDB IDs		1DS6 5H1D
Enriched GO Terms of Interacting Partners?
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