LCN2 and UBASH3A

Data Source:
BioGRID (two hybrid)

		LCN2	UBASH3A
Description		lipocalin 2	ubiquitin associated and SH3 domain containing A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Specific Granule Lumen Extracellular Exosome	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Extracellular Exosome
	Molecular Function	Iron Ion Binding Protein Binding Small Molecule Binding Identical Protein Binding Enterobactin Binding	Protein Binding
	Biological Process	Cellular Iron Ion Homeostasis Apoptotic Process Siderophore Transport Cytokine-mediated Signaling Pathway Antimicrobial Humoral Response Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Sequestering Of Iron Ion Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport
Drugs		Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
Diseases
GWAS			Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 21829393 25751624 19430480 30572963 18840781) Vitiligo ( 20410501 27723757)
Interacting Genes		61 interacting genes: ALDH7A1 ALKBH4 ASB10 ASPH BEX2 BMF C20orf85 CAMLG CCNC CDSN CHIC2 CLMP CTDSP2 EHHADH FAAP20 FAM25A FAM25C FAM25G HDDC2 HGF LAIR2 LNPEP LRP2 LY96 MAGED4B MMP2 MMP9 MSRB3 MYDGF NDUFB2 NEIL2 ODAPH P4HB PDIA4 PELI1 PICK1 PIN1 POLL POU4F2 PRKAA2 PTRH1 RAMP2 SCNM1 SEC61G SGTA SGTB TBC1D21 TRAPPC2L TRH TRIAP1 TRIM32 TSG101 TTC23 TXN2 UBASH3A UBE2F UBQLN1 UBQLN2 VEZF1 XRN2 ZBED1	89 interacting genes: ARRDC1 ARRDC3 BCAR3 C9orf24 CBLB CBS CCDC33 CD3E COPS9 DAZAP2 DDIT4L DISC1 DLGAP4 DNM2 DTX3 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 N4BP3 NSMF PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SNRNP48 SOS1 SPRY1 SPRY2 STX11 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 UBB UBC UBE2L3 VCP VPS37B WAS WASL WBP11 ZBTB42 ZC2HC1C ZNF219 ZNF474 ZRANB1
Entrez ID		3934	53347
HPRD ID		02551	06904
Ensembl ID		ENSG00000148346	ENSG00000160185
Uniprot IDs		P80188	P57075
PDB IDs		1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU 6S8V 6SUA	2CRN 5WDI
Enriched GO Terms of Interacting Partners?
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