ARHGAP1 and RHOC

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARHGAP1	RHOC
Description		Rho GTPase activating protein 1	ras homolog family member C
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GO Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Sorting Endosome	Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cleavage Furrow Stereocilium Cell Projection Neuron Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding Cadherin Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Endosomal Transport Transferrin Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Endocytic Recycling	Mitotic Cytokinesis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Positive Regulation Of Cell Migration Cortical Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Wound Healing, Spreading Of Cells Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration
Pathways		Rho GTPase cycle	Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Bone mineral density (hip) ( 19801982) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Femoral neck bone mineral density ( 22504420) Neurociticism ( 29500382) Reaction time ( 29844566) Schizophrenia ( 29483656) Suffering from nerves ( 29500382)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		25 interacting genes: ADGRB2 AGTRAP BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B LINC01554 MTNR1B PIK3R1 PTPN11 RAC1 RASA1 RHOA RHOC SH3GL1 SMARCD3 SRC TAX1BP1 TUBA4A WAS	8 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 RIPOR3 ROCK1 RTKN
Entrez ID		392	389
HPRD ID		04108	01322
Ensembl ID		ENSG00000175220	ENSG00000155366
Uniprot IDs		Q07960	A0A024R0C8 P08134
PDB IDs		1AM4 1GRN 1OW3 1RGP 1TX4 2NGR 5M6X 5M70 6R3V	1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?
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