LAMC2 and SCAP

Data Source:
BioGRID (affinity chromatography technology)

		LAMC2	SCAP
Description		laminin subunit gamma 2	SREBF chaperone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Heparin Binding	Protein Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding
	Biological Process	Cell Adhesion Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Epidermis Development Animal Organ Morphogenesis Tissue Development Dendrite Development Extracellular Matrix Organization Positive Regulation Of Cell Migration Hemidesmosome Assembly	Response To Hypoxia Immune Response Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Acne (severe) ( 30542056) Blood protein levels ( 30072576 29875488) Clozapine-induced agranulocytosis ( 25187353) HDL cholesterol ( 21347282) Low density lipoprotein cholesterol levels ( 32154731) Morning person ( 30696823) Systemic lupus erythematosus ( 21408207)	Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SLA2	5 interacting genes: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2
Entrez ID		3918	22937
HPRD ID		01031	03300
Ensembl ID		ENSG00000058085	ENSG00000114650
Uniprot IDs		Q13753	B7Z6H0 Q12770
PDB IDs
Enriched GO Terms of Interacting Partners?
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