SCAP and PGRMC1

Data Source:
HPRD (in vivo)

		SCAP	PGRMC1
Description		SREBF chaperone	progesterone receptor membrane component 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex	Mitochondrial Outer Membrane Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Endomembrane System Membrane Smooth Endoplasmic Reticulum Membrane Specific Granule Membrane Neuron Projection Neuronal Cell Body Cell Body Synapse
	Molecular Function	Protein Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding	Amyloid-beta Binding Steroid Binding Protein Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Response To Hypoxia Immune Response Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading	Heme Biosynthetic Process Neutrophil Degranulation
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)	Neutrophil degranulation
Drugs			Dextromethorphan Nortriptyline Sertraline
Diseases
GWAS		Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		5 interacting genes: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2	20 interacting genes: BIK CAMLG CCDC134 CENPU CIAO1 CREB3L1 DEFB124 EVI2B GET3 GLP1R GOLM1 KASH5 KCNE5 MTNR1A PAM16 PGRMC2 SCAP SGTB TMEM213 ZNF71
Entrez ID		22937	10857
HPRD ID		03300	02338
Ensembl ID		ENSG00000114650	ENSG00000101856
Uniprot IDs		B7Z6H0 Q12770	O00264 Q6IB11
PDB IDs			4X8Y
Enriched GO Terms of Interacting Partners?
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