LAMB2 and ORC5

Data Source:
BioGRID (two hybrid)

		LAMB2	ORC5
Description		laminin subunit beta 2	origin recognition complex subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-3 Complex Endoplasmic Reticulum Lumen Neuromuscular Junction Synaptic Cleft Laminin Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Axon Guidance Neuromuscular Junction Development Visual Perception Animal Organ Morphogenesis Tissue Development Astrocyte Development Schwann Cell Development Cell Migration Extracellular Matrix Organization Substrate Adhesion-dependent Cell Spreading Post-translational Protein Modification Cellular Protein Metabolic Process Axon Extension Involved In Regeneration Retina Development In Camera-type Eye Basement Membrane Assembly Metanephric Glomerular Visceral Epithelial Cell Development Metanephric Glomerular Basement Membrane Development	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases		Pierson syndrome
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) PR interval ( 32439900) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)
Interacting Genes		9 interacting genes: ATXN7 KPNA2 ORC5 PIK3R2 PLEKHA5 RBL1 STAT3 TSR2 ZNF512B	30 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 H3-4 H4-16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2
Entrez ID		3913	5001
HPRD ID		01034	09086
Ensembl ID		ENSG00000172037	ENSG00000164815
Uniprot IDs		P55268	A4D0P7 O43913 Q53FC8
PDB IDs			5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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