RHOB and ARHGEF3

Data Source:
HPRD (in vivo)

		RHOB	ARHGEF3
Description		ras homolog family member B	Rho guanine nucleotide exchange factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Early Endosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Cytoplasmic Vesicle Late Endosome Membrane Cleavage Furrow Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding	Protein Binding
	Biological Process	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Endosome To Lysosome Transport Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Cell Migration Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		GPVI-mediated activation cascade Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs		Botulinum toxin type A
Diseases
GWAS		Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Asthma ( 32296059) Attention function in attention deficit hyperactive disorder ( 26174813) Blood protein levels ( 28240269) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Idiopathic dilated cardiomyopathy ( 29495422) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean platelet volume ( 22139419 24026423 19110211 19820697 31194788 32888494 27863252 28031487) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Obesity-related traits ( 23251661) Platelet count ( 26805783 22139419 24026423 29066854 23263863 29403010 32888494 27863252 28031487) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 21452313) Systolic blood pressure ( 30578418)
Interacting Genes		12 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PPP2CA RHPN2 SMURF1 TNFAIP1	9 interacting genes: CEP70 HSF2BP PBX4 PICK1 RHOA RHOB TERF1 TRIM23 TRIM27
Entrez ID		388	50650
HPRD ID		01321	12480
Ensembl ID		ENSG00000143878	ENSG00000163947
Uniprot IDs		P62745	B7Z6B2 E9PG37 Q9NR81
PDB IDs		2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?
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