KRT18 and USH2A

Data Source:
HPRD (in vitro, two hybrid)

		KRT18	USH2A
Description		keratin 18	usherin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Intermediate Filament Adherens Junction External Side Of Plasma Membrane Protein-containing Complex Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Exosome	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Basement Membrane Cytoplasm Integral Component Of Membrane Apical Plasma Membrane Photoreceptor Connecting Cilium Stereocilium Bundle Ciliary Basal Body Neuronal Cell Body Terminal Bouton Stereocilium Membrane Periciliary Membrane Compartment USH2 Complex
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Protein Binding Collagen Binding Myosin Binding Identical Protein Binding
	Biological Process	Cell Cycle Anatomical Structure Morphogenesis Response To Fructose Viral Process Keratinization Response To Nutrient Levels Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Cornification Hepatocyte Differentiation Mesenchymal Stem Cell Differentiation Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Cell-cell Adhesion Cholangiocyte Apoptotic Process	Visual Perception Sensory Perception Of Sound Animal Organ Morphogenesis Tissue Development Cell Migration Substrate Adhesion-dependent Cell Spreading Hair Cell Differentiation Establishment Of Protein Localization Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Response To Stimulus Sensory Perception Of Light Stimulus Inner Ear Receptor Cell Differentiation
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases			Usher syndrome (US) Retinitis pigmentosa (RP)
GWAS		Cleft lip with or without cleft palate ( 28054174) Diffusing capacity of carbon monoxide ( 30694715) Nonsyndromic cleft lip with cleft palate ( 28232668)	Birth weight ( 31043758) Cholesterol ( 31902109) Chronic mucus hypersecretion ( 25234806) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Prepulse inhibition of the startle response ( 31596458)
Interacting Genes		91 interacting genes: BBS1 BBS2 BBS4 BBS7 C1orf109 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCHCR1 CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EFHC1 EGFR EP300 ESR1 EXOC8 FRAT1 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 HSPB1 IKBKG KIFC3 KPNA2 KRT15 KRT5 KRT6A KRT6C KRT71 KRT72 KRT79 KRT8 KRT81 LDOC1 LINC01554 MAPK14 NEFL NME7 ORC5 PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE PSTPIP2 RAF1 RCOR3 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SVIL SYCE1 TCHP TEKT4 TNFRSF1B TRADD TSG101 TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A WBP2 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ	3 interacting genes: BRCA1 COL4A3 KRT18
Entrez ID		3875	7399
HPRD ID		01020	09759
Ensembl ID		ENSG00000111057	ENSG00000042781
Uniprot IDs		A0A024RAY2 P05783	O75445
PDB IDs
Enriched GO Terms of Interacting Partners?
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