KRT6A and PRPH

Data Source:
BioGRID (affinity chromatography technology)

		KRT6A	PRPH
Description		keratin 6A	peripherin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Membrane Keratin Filament Extracellular Exosome	Cytoplasm Intermediate Filament Membrane Axon Perikaryon Type III Intermediate Filament Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of Cytolysis By Symbiont Of Host Cells Morphogenesis Of An Epithelium Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Cell Differentiation Keratinization Wound Healing Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cornification Negative Regulation Of Entry Of Bacterium Into Host Cell	Intermediate Filament Cytoskeleton Organization
Pathways		Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Cutaneous squamous cell carcinoma ( 32041948)	Prostate cancer ( 21743467) Sural nerve amplitude potential ( 30992453)
Interacting Genes		38 interacting genes: BEX2 CCDC85B DSP GEM GOLGA2 HGS KDM1A KIFC3 KRT13 KRT15 KRT16 KRT17 KRT18 KRT19 KRT25 KRT26 KRT27 KRT28 KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 LMNA MTUS2 NCALD NUP62 SGTA SMARCB1 TCHP TFIP11 TRIM23 TRIM54 TSGA10 TXLNB UBQLN2 WASHC3	36 interacting genes: CDC37 CT55 DDX6 DES FCHO1 INCA1 KIFC3 KRT14 KRT15 KRT16 KRT19 KRT20 KRT24 KRT27 KRT31 KRT75 LCA5L LENG1 LMNB1 LNX1 MAGOHB MYO5A NXF1 PIAS2 PPP1R13B PPP1R18 PRKAA2 PRPH2 PSMA1 TCEA2 TCP10L TTC23 VIM ZC4H2 ZMAT2 ZNF572
Entrez ID		3853	5630
HPRD ID		01011	01365
Ensembl ID		ENSG00000205420	ENSG00000135406
Uniprot IDs		A0A0S2Z428 P02538	B3KWQ6 P41219
PDB IDs		5KI0
Enriched GO Terms of Interacting Partners?
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