KPNA1 and NOSIP

Data Source:
BioGRID (pull down)

		KPNA1	NOSIP
Description		karyopherin subunit alpha 1	nitric oxide synthase interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Host Cell Glutamatergic Synapse	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	RNA Binding Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Modulation By Virus Of Host Cellular Process Regulation Of Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Intracellular Transport Of Virus Postsynapse To Nucleus Signaling Pathway	Multicellular Organism Development Protein Ubiquitination Negative Regulation Of Catalytic Activity Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Nitric-oxide Synthase Activity
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production	NOSIP mediated eNOS trafficking
Drugs
Diseases
GWAS		Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		45 interacting genes: ANP32A ANP32B ARNT BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMNB1 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP50 NUP54 NUP62 ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1	6 interacting genes: KPNA1 NOS1 NOS3 PPP2CA UBE2D3 ZNF410
Entrez ID		3836	51070
HPRD ID		02819	17642
Ensembl ID		ENSG00000114030	ENSG00000142546
Uniprot IDs		B3KXZ2 P52294	A0A075B6F9 Q9Y314
PDB IDs		2JDQ 3TJ3 4B18 6WX9
Enriched GO Terms of Interacting Partners?
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