KIT and GRB10

  • Data Source:
  • BioGRID (two hybrid, pull down, affinity chromatography technology)
  • HPRD (two hybrid, in vitro, in vivo)

KIT

GRB10

Description KIT proto-oncogene, receptor tyrosine kinase growth factor receptor bound protein 10
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acute lymphoblastic leukemia (childhood) ( 23512250)
  • Area under the curve of insulin levels ( 24699409)
  • Birth weight ( 31043758)
  • Blood pressure (smoking interaction) ( 25189868)
  • Body mass index ( 26426971)
  • Body mass index (age <50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Brain morphology (MOSTest) ( 32665545)
  • Chronotype ( 30696823)
  • Corpus callosum mid-anterior volume ( 31530798)
  • Corrected insulin response ( 24699409)
  • Corrected insulin response adjusted for insulin sensitivity index ( 24699409)
  • Diastolic blood pressure ( 30224653)
  • Eosinophil counts ( 32888494 27863252)
  • Estimated glomerular filtration rate ( 31152163 31015462)
  • Fasting blood glucose ( 22581228)
  • Fasting blood glucose (BMI interaction) ( 22581228)
  • Femoral neck bone mineral density ( 22504420)
  • Fractures ( 30158200)
  • Heel bone mineral density ( 30598549)
  • Incremental insulin ( 24699409)
  • Insulin levels adjusted for BMI ( 24699409)
  • Insulin-related traits (multivariate analysis) ( 32002517)
  • Mean corpuscular volume ( 32888494)
  • Mean reticulocyte volume ( 32888494)
  • Metabolite levels ( 23823483)
  • Morning person ( 30696823)
  • Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409)
  • Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901)
  • Schizophrenia (treatment resistant) ( 25223841)
  • Subcortical volume (MOSTest) ( 32665545)
  • Sum eosinophil basophil counts ( 27863252)
  • Systemic sclerosis ( 21779181)
  • Total body bone mineral density ( 29304378)
Interacting Genes 92 interacting genes: ABL1 ABL2 BCAR3 BLK BLNK BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF1R CSF2RA CSF2RB DOK1 EPOR FES FGR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK HSH2D IL7R ILKAP INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ NCK1 NCK2 PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCE1 PLCG1 PLCG2 PRKCA PRKCB PTK6 PTPN11 PTPN20 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SLA2 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B STYX SYK TEC TNS1 TNS2 TNS3 TXK VAV3 YES1 ZAP70 48 interacting genes: AANAT ABL1 AKT1 APP BAIAP2 BCR BLK CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 ERBB2 ERBB4 FARS2 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KANK2 KDR KIT KPNA3 MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NFKBID NOA1 PDGFRB PICK1 RAF1 RET SRC TEKT4 TEPSIN TNK1 TRIM55 TRIM63 TXK ZDHHC17 ZMYND19
Entrez ID 3815 2887
HPRD ID 01287 03312
Ensembl ID ENSG00000157404 ENSG00000106070
Uniprot IDs A0A0U2N547 P10721 Q13322
PDB IDs 1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2IUH 2VIF 3G0E 3G0F 4HVS 4K94 4K9E 4PGZ 4U0I 6GQJ 6GQK 6GQL 6GQM 6HH1 6ITT 6ITV 6KLA 6MOB 6XV9 6XVA 6XVB 1NRV 3HK0
Enriched GO Terms of Interacting Partners?
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