KCNQ2 and ARIH2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KCNQ2	ARIH2
Description		potassium voltage-gated channel subfamily Q member 2	ariadne RBR E3 ubiquitin protein ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Node Of Ranvier Axon Initial Segment Synapse	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Ankyrin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Chemical Synaptic Transmission Nervous System Development Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Voltage gated Potassium channels Interaction between L1 and Ankyrins	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Enflurane Amitriptyline Meclofenamic acid Promethazine Miconazole Ezogabine ICA-105665
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Perceived intensity of neohesperidin dihydrochalcone ( 31005972)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)
Interacting Genes		6 interacting genes: ARIH2 CALM1 CALM2 CALM3 KCNQ3 PRKCA	50 interacting genes: APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R KAT5 KCNQ2 MEOX2 NEDD8 PAX6 PHF7 PPP2R1A PTN REL RHEB RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91
Entrez ID		3785	10425
HPRD ID		03757	09286
Ensembl ID		ENSG00000075043	ENSG00000177479
Uniprot IDs		O43526 Q53Y30	O95376 Q53ET9 Q6IBL8
PDB IDs		5J03 6FEG 6FEH 7CR0 7CR1 7CR2 7CR3 7CR4 7CR7
Enriched GO Terms of Interacting Partners?
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