KCNN1 and RAB8A

Data Source:
BioGRID (proximity labelling technology)

		KCNN1	RAB8A
Description		potassium calcium-activated channel subfamily N member 1	RAB8A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Neuron Projection Neuronal Cell Body Synapse	Golgi Membrane Endosome Centrosome Centriole Cytosol Plasma Membrane Cilium Synaptic Vesicle Postsynaptic Density Trans-Golgi Network Transport Vesicle Midbody Phagocytic Vesicle Membrane Trans-Golgi Network Membrane Neuronal Cell Body Dendritic Spine Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome Non-motile Cilium Glutamatergic Synapse
	Molecular Function	Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein-containing Complex Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding
	Biological Process	Ion Transport Potassium Ion Transport Chemical Synaptic Transmission Potassium Ion Transmembrane Transport	Vesicle Docking Involved In Exocytosis Autophagy Axonogenesis Protein Secretion Regulation Of Autophagy Regulation Of Exocytosis Cellular Response To Insulin Stimulus Post-translational Protein Modification Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		Ca2+ activated K+ channels	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Procaine Miconazole Trimebutine
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Mean reticulocyte volume ( 32888494)	Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: CALM1 CALM2 CALM3	23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC
Entrez ID		3780	4218
HPRD ID		04282	01296
Ensembl ID		ENSG00000105642	ENSG00000167461
Uniprot IDs		Q92952	A0A024R7I3 P61006
PDB IDs			3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6ZSI 6ZSJ
Enriched GO Terms of Interacting Partners?
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