USP17L2 and KMT5A

Data Source:
BioGRID (pull down)

		USP17L2	KMT5A
Description		ubiquitin specific peptidase 17 like family member 2	lysine methyltransferase 5A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Cytosol	Nucleoplasm Chromosome Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding	P53 Binding Transcription Corepressor Activity Protein Binding Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific)
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Mitotic Cell Cycle Checkpoint Negative Regulation Of Protein Processing Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Cell Migration Negative Regulation Of Histone Deacetylation Negative Regulation Of GTPase Activity Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Defense Response To Virus By Host Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination CAAX-box Protein Processing Negative Regulation Of Protein Targeting To Membrane Regulation Of Ruffle Assembly Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Cell Cycle Peptidyl-lysine Monomethylation Histone H4-K20 Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Ub-specific processing proteases RAS processing	Condensation of Prophase Chromosomes PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) High density lipoprotein cholesterol levels ( 29403010)
Interacting Genes		7 interacting genes: BRD4 CDK4 CDK6 ELK1 KMT5A LGMN SNAI1	11 interacting genes: BTRC DTL E2F2 FAM9A H4-16 PCNA TCF7L2 TP53 TWIST1 UBE2I USP17L2
Entrez ID		377630	387893
HPRD ID		16844	06254
Ensembl ID		ENSG00000223443	ENSG00000183955
Uniprot IDs		Q6R6M4	E3VVS3 Q9NQR1
PDB IDs			1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8 5HQ2 5T5G 5TEG 5TH7 5V2N 5W1Y 6BOZ
Enriched GO Terms of Interacting Partners?
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