JAG2 and MIB2

Data Source:
BioGRID (pull down)

		JAG2	MIB2
Description		jagged canonical Notch ligand 2	MIB E3 ubiquitin protein ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Ubiquitin Ligase Complex Cytoplasm Early Endosome Cytosol
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Growth Factor Activity	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Skeletal System Development In Utero Embryonic Development Respiratory System Process Notch Signaling Pathway Spermatogenesis Auditory Receptor Cell Fate Commitment Morphogenesis Of Embryonic Epithelium Cell Differentiation Regulation Of Cell Adhesion T Cell Differentiation Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Gamma-delta T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Notch Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis	Protein Polyubiquitination Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Fasting plasma glucose ( 31932636) Red blood cell count ( 32888494)	Body mass index ( 26426971) Height ( 31562340) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295)
Interacting Genes		8 interacting genes: ATN1 ATXN7 CACNA1A GFI1B MIB2 NOTCH1 NOTCH2 NOTCH3	10 interacting genes: ACTA1 ACTC1 BCL10 GRIN2B JAG2 SRPK2 TBK1 UBE2D2 UBE2N UBE2U
Entrez ID		3714	142678
HPRD ID		03981	15905
Ensembl ID		ENSG00000184916	ENSG00000197530
Uniprot IDs		Q9Y219	Q96AX9
PDB IDs		5MW5 5MW7 5MWF
Enriched GO Terms of Interacting Partners?
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