ITGB6 and VTN

Data Source:
HPRD (in vitro)

		ITGB6	VTN
Description		integrin subunit beta 6	vitronectin
Image
GO Annotations	Cellular Component	Nucleoplasm Centrosome Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Cell Junction Integrin Alphav-beta6 Complex Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Polysaccharide Binding
	Biological Process	Cell Morphogenesis Inflammatory Response Immune Response Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Surfactant Homeostasis Skin Development Viral Entry Into Host Cell Lung Alveolus Development Phospholipid Homeostasis Hard Palate Development Bone Development SMAD Protein Signal Transduction Bronchiole Development Langerhans Cell Differentiation Enamel Mineralization Cellular Response To Ionizing Radiation Transforming Growth Factor Beta Production Regulation Of Transforming Growth Factor Beta Activation	Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing
Pathways		Elastic fibre formation Molecules associated with elastic fibres Integrin cell surface interactions ECM proteoglycans	Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade
Drugs			Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Eosinophil counts ( 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) Idiopathic membranous nephropathy ( 21323541) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Tourette syndrome ( 30818990) Type 2 diabetes ( 20418489) Waist circumference adjusted for body mass index ( 25673412)	Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Osteoprotegerin levels ( 25080503)
Interacting Genes		8 interacting genes: FHL2 FLNA FLNB FN1 ITGAV MAPK1 TGFB1 VTN	47 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA
Entrez ID		3694	7448
HPRD ID		00947	01902
Ensembl ID		ENSG00000115221	ENSG00000109072
Uniprot IDs		A0A087WXP3 B4E2B8 E9PEE8 P18564	D9ZGG2 P04004
PDB IDs		1LH9 4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU	1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E
Enriched GO Terms of Interacting Partners?
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