ITGB5 and P2RY2

Data Source:
HPRD (in vivo, in vitro)

		ITGB5	P2RY2
Description		integrin subunit beta 5	purinergic receptor P2Y2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity	Protein Binding Signaling Receptor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Muscle Contraction Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Stress Fiber Assembly Viral Entry Into Host Cell Epithelial Cell-cell Adhesion	Cellular Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Mucus Secretion Cellular Response To ATP Blood Vessel Diameter Maintenance
Pathways		Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction	G alpha (q) signalling events P2Y receptors Surfactant metabolism
Drugs			Promethazine Suramin Denufosol INS 316
Diseases
GWAS		Airway hyperresponsiveness ( 23984888) Carpal tunnel syndrome ( 30833571) Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin concentration ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)	Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Body mass index in asthmatics ( 23517042) Dentures ( 31235808) Glucose homeostasis traits ( 25524916) Insomnia (caffeine-induced) ( 22754043) Monocyte percentage of white cells ( 32888494) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		58 interacting genes: ANXA5 APPBP2 CCN1 CYSRT1 DAB1 DAB2 DOK1 EFEMP2 EHMT2 EPS8 EWSR1 FDFT1 FHL2 FHL3 FLNA GAPDH GOLGA2 GON4L ITGA5 ITGAV ITGB3BP KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP5-7 LTBP1 LTBP3 MTDH MTUS2 MYBPC2 MYO10 NBPF19 NOTCH2NLA NUMB P2RY2 PAK4 PALLD PPARD PTK2 RACK1 SNTA1 SPP1 SRSF9 STAB2 TAF1 TLN1 TNS2 TRIM55 TRIM63 TTN ZBTB17 ZNF655	7 interacting genes: APP CD47 ITGAV ITGB3 ITGB5 KDR SRC
Entrez ID		3693	5029
HPRD ID		00949	02499
Ensembl ID		ENSG00000082781	ENSG00000175591
Uniprot IDs		D3DNA1 L7RT22 P18084	P41231
PDB IDs			1Z8E
Enriched GO Terms of Interacting Partners?
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