ITGB2 and C3

Data Source:
BioGRID (pull down)

		ITGB2	C3
Description		integrin subunit beta 2	complement C3
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Specific Granule Membrane Receptor Complex Plasma Membrane Raft Extracellular Exosome Tertiary Granule Membrane Cytoplasmic Region Ficolin-1-rich Granule Membrane Extracellular Vesicle	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Heat Shock Protein Binding Cargo Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding
	Biological Process	Microglial Cell Activation Leukocyte Migration Involved In Inflammatory Response Receptor-mediated Endocytosis Phagocytosis, Engulfment Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Regulation Of Cell Shape Cell Migration Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Superoxide Anion Generation Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Endothelial Cell Migration Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Dopamine Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Neuron Death Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Migration Positive Regulation Of Prostaglandin-E Synthase Activity	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Response To Bacterium Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Glucose Transmembrane Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Negative Regulation Of Endopeptidase Activity Neuron Remodeling Regulation Of Complement Activation Oviduct Epithelium Development Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Immune Response Positive Regulation Of Phagocytosis, Engulfment Amyloid-beta Clearance Complement-dependent Cytotoxicity Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling Positive Regulation Of Apoptotic Cell Clearance
Pathways		Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Alternative complement activation Activation of C3 and C5 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (i) signalling events Neutrophil degranulation Post-translational protein phosphorylation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade
Drugs			Human immunoglobulin G Zinc S-Hydroxycysteine Mirococept Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Heel bone mineral density ( 28869591) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 20861866 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576 29875488) Complement C3 and C4 levels ( 23028341) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Triglycerides ( 24097068) White blood cell count ( 32888494)
Interacting Genes		56 interacting genes: ADAMTSL4 APOL2 C3 CD14 CD226 CD82 COPS3 COPS5 CYSRT1 CYTH1 CYTH2 DAB1 DOK1 EGFR ESM1 FCER2 FHL2 FUT4 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 KRT31 KRTAP10-8 LHFPL5 MS4A7 MTIF3 NBPF19 NOTCH2NLA NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RACK1 RANBP9 RDX SCML1 SHARPIN SYK TLN1 TM4SF18 UPK1B VNN2	36 interacting genes: ABL1 AGR2 ATG16L1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG EFEMP2 GC GOLGA6L9 HMGB1 ITGAM ITGAX ITGB2 KRT31 KRTAP10-8 LAMA1 LRP1 MASP1 OLFM4 PAPPA PLEKHF2 TGM2 VSIG4
Entrez ID		3689	718
HPRD ID		02506	00400
Ensembl ID		ENSG00000160255	ENSG00000125730
Uniprot IDs		A0A494C0X7 B4E0R1 P05107	B4DR57 P01024 V9HWA9
PDB IDs		1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4 5XR1 5ZAZ	1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76 4ONT 4ZH1 5FO7 5FO8 5FO9 5FOA 5FOB 5NBQ 5O32 5O35 6EHG 6RUR 6RUV 6S0B
Enriched GO Terms of Interacting Partners?
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