ITGAX and JAM3

Data Source:
HPRD (in vivo)

		ITGAX	JAM3
Description		integrin subunit alpha X	junctional adhesion molecule 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane Secretory Granule Membrane Integrin AlphaX-beta2 Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Bicellular Tight Junction Desmosome Filamentous Actin Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone Tight Junction Protein Complex Involved In Cell Adhesion
	Molecular Function	Integrin Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Metal Ion Binding	Integrin Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell-cell Adhesion Mediator Activity
	Biological Process	Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Myelination Heterotypic Cell-cell Adhesion Neutrophil Degranulation Positive Regulation Of Angiogenesis Leukocyte Migration Positive Regulation Of Endothelial Tube Morphogenesis	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Cellular Extravasation Cell-matrix Adhesion Spermatid Development Transmission Of Nerve Impulse Establishment Of Cell Polarity Extracellular Matrix Organization Axon Regeneration Negative Regulation Of Integrin Activation Negative Regulation Of Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Myelination Apical Protein Localization Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Hematopoietic Stem Cell Migration To Bone Marrow Granulocyte Migration Cell-cell Adhesion Protein Localization To Cell Junction Positive Regulation Of Membrane Permeability
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Cell surface interactions at the vascular wall Integrin cell surface interactions
Drugs		Efalizumab
Diseases
GWAS		IgA nephropathy ( 25305756) Post bronchodilator FEV1 ( 26634245) Systemic lupus erythematosus ( 18204098)	Blood protein levels ( 30072576) Neutrophil count ( 32888494)
Interacting Genes		5 interacting genes: C3 FCER2 ITGB2 JAM3 MIA3	8 interacting genes: F2RL2 ITGAM ITGAX JAM2 MEOX2 PICK1 RHOU TJP1
Entrez ID		3687	83700
HPRD ID		01051	06042
Ensembl ID		ENSG00000140678	ENSG00000166086
Uniprot IDs		H3BN02 P20702	Q9BX67
PDB IDs		1N3Y 2LUV 3K6S 3K71 3K72 4NEH 4NEN 5ES4
Enriched GO Terms of Interacting Partners?
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