PDX1 and MAFA

Data Source:
HPRD (in vitro, in vivo)

		PDX1	MAFA
Description		pancreatic and duodenal homeobox 1	MAF bZIP transcription factor A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Factor Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Nitric Oxide Mediated Signal Transduction Central Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Wounding Animal Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Animal Organ Senescence Positive Regulation Of Cell Death Morphogenesis Of Embryonic Epithelium Insulin Secretion Exocrine Pancreas Development Animal Organ Regeneration Response To Vitamin Response To Cytokine Response To Nicotine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Drug Glucose Homeostasis Response To Leucine Response To Alkaloid Positive Regulation Of DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Response To Glucocorticoid Detection Of Glucose Transdifferentiation Response To Fatty Acid Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Nitric Oxide Mediated Signal Transduction Response To Glucose Insulin Secretion Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in early pancreatic precursor cells	Regulation of gene expression in beta cells
Drugs
Diseases		Maturity onset diabetes of the young (MODY) Pancreatic agenesis Permanent neonatal diabetes mellitus (PNDM)
GWAS		Acute insulin response ( 28490609) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Birth weight ( 31043758) Blood sugar levels ( 29403010) Body mass index ( 26426971) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 28270201) Glycated hemoglobin levels ( 28898252) Pancreatic cancer ( 29422604 26098869 25086665) Peak insulin response ( 28490609)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Nonsyndromic cleft palate ( 31609978)
Interacting Genes		13 interacting genes: ATF3 CREB1 IAPP MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6	5 interacting genes: MAF MAPK1 MAPK14 NEUROD1 PDX1
Entrez ID		3651	389692
HPRD ID		02843	14346
Ensembl ID		ENSG00000139515	ENSG00000182759
Uniprot IDs		P52945	Q8NHW3
PDB IDs		6F8F	4EOT
Enriched GO Terms of Interacting Partners?
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