INCENP and EVI5

Data Source:
BioGRID (pull down)

		INCENP	EVI5
Description		inner centromere protein	ecotropic viral integration site 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome Lateral Element Central Element Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Nuclear Body Midbody Chromosome Passenger Complex Protein-containing Complex Meiotic Spindle Midzone	Nucleus Microtubule Organizing Center Spindle Cytosol
	Molecular Function	Protein Binding Protein Serine/threonine Kinase Activator Activity	GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cytokinesis Chromosome Segregation Meiotic Chromosome Condensation Histone Phosphorylation Meiotic Spindle Midzone Assembly Metaphase Plate Congression Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cytokinesis	Intracellular Protein Transport Cell Cycle Retrograde Transport, Endosome To Golgi Positive Regulation Of GTPase Activity Cell Division Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Reversine
Diseases
GWAS		Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Apolipoprotein B levels ( 32203549) Asthma or allergic disease (pleiotropy) ( 29785011) Cholesterol, total ( 24097068 25961943 20686565) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) LDL cholesterol ( 30275531 25961943) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 24076602 19525955 21833088 27386562) Systemic lupus erythematosus ( 28714469) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		10 interacting genes: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AZ1 H3C14	22 interacting genes: ARL4A AURKB BIRC5 CCDC185 CEP19 CSNK1D ELOA FAM161A FBXO5 IMP3 INCENP LENG1 LMO1 MB21D2 MCRS1 MORF4L2 PRPF31 REP15 STX3 TCEANC TNFAIP8L1 ZNF446
Entrez ID		3619	7813
HPRD ID		05103	04249
Ensembl ID		ENSG00000149503	ENSG00000067208
Uniprot IDs		Q9NQS7	O60447 Q59FE7
PDB IDs		2QFA 4AF3 5IEH 5IEK 6GR8 6GR9 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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