IMPDH2 and FBXL7

Data Source:
BioGRID (affinity chromatography technology)

		IMPDH2	FBXL7
Description		inosine monophosphate dehydrogenase 2	F-box and leucine rich repeat protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Ubiquitin Ligase Complex Centrosome Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cell Division
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Adverse response to drug ( 30420678) Alzheimer's disease (late onset) ( 26339675) Asthma (corticosteroid response) ( 24486069) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (feminism/equality) ( 22566634) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Response to fenofibrate (total cholesterol levels) ( 27002377) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Visceral fat ( 22589738)
Interacting Genes		15 interacting genes: AGR2 AKT1 ANKRD9 APIP CLK1 CPLANE2 IL1F10 IMPDH1 PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4	5 interacting genes: APP BIRC5 FBXL18 FCHO1 TBC1D5
Entrez ID		3615	23194
HPRD ID		00895	05740
Ensembl ID		ENSG00000178035	ENSG00000183580
Uniprot IDs		A0A384N6C2 P12268	Q9UJT9
PDB IDs		1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ
Enriched GO Terms of Interacting Partners?
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