IL13RA1 and IL13

Data Source:
HPRD (in vivo)

		IL13RA1	IL13
Description		interleukin 13 receptor subunit alpha 1	interleukin 13
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GO Annotations	Cellular Component	Plasma Membrane Interleukin-13 Receptor Complex External Side Of Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding	Cytokine Activity Interleukin-13 Receptor Binding Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Regulation Of Proton Transport Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of NAD(P)H Oxidase Activity Response To Nicotine Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Ethanol Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Interleukin-4 and Interleukin-13 signaling	Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling
Drugs			Cintredekin Besudotox Lebrikizumab
Diseases			Asthma Graft-versus-host disease
GWAS		Body mass index ( 28892062) Type 2 diabetes ( 30718926)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 31361310 31959851 20860503 32296059 31619474 29785011 29273806) Asthma (childhood onset) ( 24241537 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 23886662 25574825 26482879 23727859) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 22286212 24920014) IgE levels ( 22075330) Inflammatory bowel disease ( 23128233) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Psoriasis ( 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Rosacea symptom severity ( 29771307)
Interacting Genes		6 interacting genes: DLG4 IL13 IL4R TMEM39B TRAF3IP1 TYK2	5 interacting genes: IL13RA1 IL13RA2 IL4R PIK3R1 VCAM1
Entrez ID		3597	3596
HPRD ID		02125	00981
Ensembl ID		ENSG00000131724	ENSG00000169194
Uniprot IDs		P78552	P35225
PDB IDs		3BPN 3BPO 4HWB 5E4E	1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y
Enriched GO Terms of Interacting Partners?
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