IL4R and SLC20A1

Data Source:
BioGRID (biochemical)

		IL4R	SLC20A1
Description		interleukin 4 receptor	solute carrier family 20 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Interleukin-4 Receptor Activity Protein Binding	Inorganic Phosphate Transmembrane Transporter Activity High-affinity Inorganic Phosphate:sodium Symporter Activity Sodium:phosphate Symporter Activity Signaling Receptor Activity
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant	Phosphate-containing Compound Metabolic Process Ion Transport Viral Process Biomineral Tissue Development Phosphate Ion Transmembrane Transport Sodium Ion Transmembrane Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Interleukin-4 and Interleukin-13 signaling	Sodium-coupled phosphate cotransporters
Drugs		AER001 Dupilumab
Diseases		Asthma
GWAS		Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6	3 interacting genes: BCL10 MAPK6 RAPGEF1
Entrez ID		3566	6574
HPRD ID		00990	08846
Ensembl ID		ENSG00000077238	ENSG00000144136
Uniprot IDs		B2RBY1 P24394	A7LNJ1 Q8WUM9
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL
Enriched GO Terms of Interacting Partners?
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