IL4R and ERN2

Data Source:
BioGRID (affinity chromatography technology)

		IL4R	ERN2
Description		interleukin 4 receptor	endoplasmic reticulum to nucleus signaling 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex	Integral Component Of Membrane Endoplasmic Reticulum Quality Control Compartment IRE1-TRAF2-ASK1 Complex
	Molecular Function	Interleukin-4 Receptor Activity Protein Binding	Magnesium Ion Binding Endonuclease Activity Endoribonuclease Activity Protein Serine/threonine Kinase Activity ATP Binding Unfolded Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant	MRNA Processing Protein Phosphorylation Cell Cycle Arrest Activation Of JUN Kinase Activity RRNA Catabolic Process Apoptotic Chromosome Condensation Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Transcription, DNA-templated Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Interleukin-4 and Interleukin-13 signaling
Drugs		AER001 Dupilumab
Diseases		Asthma
GWAS		Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6
Entrez ID		3566	10595
HPRD ID		00990	04944
Ensembl ID		ENSG00000077238	ENSG00000134398
Uniprot IDs		B2RBY1 P24394	A5YM46 A5YM65 E7ETG2 Q76MJ5
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL
Enriched GO Terms of Interacting Partners?
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