IL1R1 and IRAK2

Data Source:
HPRD (in vitro, in vivo)

		IL1R1	IRAK2
Description		interleukin 1 receptor type 1	interleukin 1 receptor associated kinase 2
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protease Binding Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Interleukin-1 Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway	Activation Of MAPK Activity Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		Interleukin-10 signaling Interleukin-1 signaling Potential therapeutics for SARS	MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane
Drugs		Anakinra SD118 OMS-103HP Foreskin fibroblast (neonatal)
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Ankylosing spondylitis ( 23749187) Asthma ( 31959851 30929738 31619474 29785011 22561531) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576 28240269) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		11 interacting genes: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP	20 interacting genes: ARAF HRAS IL1R1 IRAK1 IRAK3 MYD88 PELI1 PELI2 PELI3 SARM1 SMAD2 SMURF1 STT3A TARDBP TICAM2 TIRAP TLR4 TOLLIP TRAF6 ZC3H12A
Entrez ID		3554	3656
HPRD ID		00994	04491
Ensembl ID		ENSG00000115594	ENSG00000134070
Uniprot IDs		B8ZZW4 P14778	O43187
PDB IDs		1G0Y 1IRA 1ITB 4DEP 4GAF	3MOP
Enriched GO Terms of Interacting Partners?
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