IGFBP1 and MMP26

Data Source:
HPRD (in vivo, in vitro)

		IGFBP1	MMP26
Description		insulin like growth factor binding protein 1	matrix metallopeptidase 26
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus	Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Signal Transduction Aging Insulin Receptor Signaling Pathway Positive Regulation Of Cell Growth PERK-mediated Unfolded Protein Response Tissue Regeneration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway	Proteolysis Extracellular Matrix Organization Collagen Catabolic Process Negative Regulation Of Inflammatory Response
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Marimastat
Diseases
GWAS		Major depressive disorder ( 23377640) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 28135244 30487518) Rheumatoid arthritis ( 21156761) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27618447)	Coenzyme Q10 levels ( 27149984) Malaria ( 31844061) Mean corpuscular volume ( 28453575)
Interacting Genes		4 interacting genes: IGF1 IGF2 MMP26 TF	4 interacting genes: ERRFI1 IGFBP1 MMP9 SERPINA1
Entrez ID		3484	56547
HPRD ID		00897	05683
Ensembl ID		ENSG00000146678	ENSG00000167346
Uniprot IDs		P08833	Q9NRE1
PDB IDs		1ZT3 1ZT5 2DSQ
Enriched GO Terms of Interacting Partners?
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