IDUA and MPP3

Data Source:
HPRD (two hybrid)

		IDUA	MPP3
Description		alpha-L-iduronidase	membrane palmitoylated protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Coated Vesicle Lysosomal Lumen Extracellular Exosome
	Molecular Function	L-iduronidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Signaling Receptor Binding	Protein Binding
	Biological Process	Disaccharide Metabolic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Catabolic Process Heparin Catabolic Process
Pathways		HS-GAG degradation CS/DS degradation MPS I - Hurler syndrome
Drugs
Diseases		Mucopolysaccharidosis type I (MPS1); Hurler-Scheie syndrome (MPS1HS); Hurler syndrome (MPS1H); Scheie syndrome (MPS1S)
GWAS		Blood protein levels ( 30072576 29875488) Heel bone mineral density ( 30598549) Limited cutaneous systemic scleroderma ( 29293537) Lumbar spine bone mineral density ( 22504420) Mean reticulocyte volume ( 32888494) Polymyositis ( 26362759) Primary biliary cholangitis ( 26394269)	HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068)
Interacting Genes		1 interacting genes: MPP3	39 interacting genes: APP ARL2BP BTBD1 CADM1 CCDC137 CRABP1 ERBIN EZR FAM171B FBXO7 GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A LIN7B LIN7C MCM2 MDH1 NOA1 PKNOX1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZNF655 ZPR1
Entrez ID		3425	4356
HPRD ID		02016	03069
Ensembl ID		ENSG00000127415	ENSG00000161647
Uniprot IDs		P35475	D3DX46 Q13368
PDB IDs		1Y24 3W81 3W82 4KGJ 4KGL 4KH2 4MJ2 4MJ4 4OBR 4OBS 6I6R 6I6X
Enriched GO Terms of Interacting Partners?
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