ACADM and DIRAS3

Data Source:
BioGRID (two hybrid)

		ACADM	DIRAS3
Description		acyl-CoA dehydrogenase medium chain	DIRAS family GTPase 3
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Axon Mitochondrial Membrane	Plasma Membrane
	Molecular Function	Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding Medium-chain-acyl-CoA Dehydrogenase Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Fatty Acid Beta-oxidation Regulation Of Lipid Metabolic Process Carnitine Metabolic Process, CoA-linked Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Carnitine Biosynthetic Process Medium-chain Fatty Acid Metabolic Process Medium-chain Fatty Acid Catabolic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Gene Expression By Genetic Imprinting Small GTPase Mediated Signal Transduction
Pathways		PPARA activates gene expression mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Drugs		Octanoyl-Coenzyme A Flavin adenine dinucleotide 3-thiaoctanoyl-CoA
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Acylcarnitine levels ( 26068415) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Daytime sleep phenotypes ( 27126917) Glycine levels ( 31070104 30837465) Metabolic traits ( 21886157) Metabolite levels ( 20037589) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		3 interacting genes: CALM1 CDC42 SUMO4	12 interacting genes: APC BAG4 BRMS1 CHEK2 FGFR4 KRAS MEOX2 PALB2 PPM1D PTPN1 TGFB1 WT1
Entrez ID		34	9077
HPRD ID		08447	05547
Ensembl ID		ENSG00000117054	ENSG00000162595
Uniprot IDs		A0A0S2Z366 B4DJE7 B7Z9I1 P11310 Q5HYG7 Q5T4U5	O95661
PDB IDs		1EGC 1EGD 1EGE 1T9G 2A1T 4P13	6NAZ
Enriched GO Terms of Interacting Partners?
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