APOB and LIPC

Data Source:
HPRD (in vitro)

		APOB	LIPC
Description		apolipoprotein B	lipase C, hepatic type
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Vesicle Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Endocytic Vesicle Lumen	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen High-density Lipoprotein Particle
	Molecular Function	Protein Binding Phospholipid Binding Heparin Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity	Lipoprotein Lipase Activity Phospholipase Activity Lysophospholipase Activity Triglyceride Lipase Activity Heparin Binding Phospholipase A1 Activity Lipase Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Phosphatidyl Phospholipase B Activity
	Biological Process	Retinoid Metabolic Process In Utero Embryonic Development Toll-like Receptor Signaling Pathway Triglyceride Mobilization Receptor-mediated Endocytosis Spermatogenesis Nervous System Development Cholesterol Metabolic Process Fertilization Response To Virus Response To Carbohydrate Post-embryonic Development Response To Selenium Ion Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Cholesterol Transport Flagellated Sperm Motility Response To Estradiol Response To Lipopolysaccharide Cholesterol Efflux Chylomicron Remodeling Low-density Lipoprotein Particle Remodeling Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Low-density Lipoprotein Particle Clearance Very-low-density Lipoprotein Particle Clearance Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Leukocyte Migration Membrane Organization Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin Stimulus Intermembrane Lipid Transfer	Fatty Acid Biosynthetic Process Lipid Catabolic Process Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Remodeling Intermediate-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Phosphatidylcholine Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Regulation Of Lipoprotein Lipase Activity Triglyceride Homeostasis
Pathways		Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance LDL clearance LDL clearance LDL remodeling VLDL clearance VLDL clearance Retinoid metabolism and transport Retinoid metabolism and transport	Assembly of active LPL and LIPC lipase complexes Chylomicron clearance
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases		Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586) Binge eating behaviour and bipolar disorder ( 24882193) Blood protein levels ( 29875488 28240269) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 30510157) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Coronary artery disease ( 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Erectile dysfunction and prostate cancer treatment ( 20932654) Gastroesophageal reflux disease ( 31527586) HDL cholesterol ( 20864672 19060911 30275531 25961943 20686565) HDL cholesterol levels ( 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18262040 23726366 24097068 24507774 21059979 18193043 18193044 20864672 19060906 19060910 19060911 30275531 21347282 25961943 26780889 20686565 26582766) LDL cholesterol levels ( 32203549 28334899 26690388 31087446 17463246 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipid or lipoprotein levels ( 23696881) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 31969989) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 31589552) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Pancreatic cancer ( 30206226) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Red cell distribution width ( 32888494) Response to statin therapy ( 20339536) Response to statins (LDL cholesterol change) ( 31969989) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 30718733 28334899 26690388 31087446 30275531) Triglyceride levels ( 32203549 32154731 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 18193044 20864672 26160806 19060906 19060911 25961943 20686565)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636 21665990) Alzheimer's disease (cognitive decline) ( 23535033) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Amyotrophic lateral sclerosis ( 18084291) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood metabolite levels ( 24816252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol efflux capacity ( 30369316) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Cognitive performance ( 20125193) Eosinophil counts ( 32888494) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 24097068 29404214 18193043 18193044 20864672 26160806 19060906 23505323 19060910 19060911 21347282 25961943 26780889 20686565 26582766) HDL cholesterol levels ( 32203549 31694877 28334899 26690388 31087446 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 30718733 31211820 29403010 29615537) Ischemic stroke ( 26089329) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219 19936222) Lipid traits ( 24386095 24023260) Low density lipoprotein cholesterol levels ( 29403010) Lymphocyte counts ( 32888494) Lysophosphatidylethanolamine levels ( 31551469) Metabolic syndrome ( 22399527 30382898 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23281178 23823483 22916037 19043545) Metabolite levels (lipoprotein measures) ( 27005778) Monocyte count ( 32888494) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Phosphatidylethanolamine levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Postprandial triglyceride response ( 32603185) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Schizophrenia ( 26198764) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Stroke ( 26089329) Total cholesterol levels ( 28334899 29403010 29615537) Triglyceride levels ( 32203549 28334899 31087446 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 18193043 30275531 25961943 20686565 26582766) Tumor necrosis factor levels ( 32805626)
Interacting Genes		24 interacting genes: AKT2 APOA1 ARFGAP1 BGN CALR CANX CD36 HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3 TREM2	3 interacting genes: ADHFE1 APOB LRP1
Entrez ID		338	3990
HPRD ID		00133	01058
Ensembl ID		ENSG00000084674	ENSG00000166035
Uniprot IDs		P04114 Q59HB3 Q7Z7Q0	A6H8L5 P11150
PDB IDs
Enriched GO Terms of Interacting Partners?
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