KRTAP6-1 and GLIS3

Data Source:
BioGRID (two hybrid)

		KRTAP6-1	GLIS3
Description		keratin associated protein 6-1	GLIS family zinc finger 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Keratinization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Keratinization
Drugs
Diseases			Permanent neonatal diabetes mellitus (PNDM)
GWAS			Alzheimer's disease biomarkers ( 23562540) Blood sugar levels ( 29403010) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 29760442) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronic obstructive pulmonary disease ( 30804561) Circulating leptin levels or type 2 diabetes ( 32341051) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Glaucoma (primary angle closure) ( 27064256) Height ( 28552196) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Homeostasis model assessment of beta-cell function ( 20081858) Intraocular pressure ( 29617998 29785010 30054594 30591961 29235454) Low high density lipoprotein cholesterol levels ( 26879886) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Methotrexate phramacokinetics (acute lymphoblastic leukemia) ( 19901119) Monocyte count ( 32888494) Neurociticism ( 29500382) Nicotine dependence ( 28440896) Offspring birth weight ( 31043758) Osteoarthritis of the hip or knee ( 29436472) Osteoarthritis of the hip or knee (with total joint replacement) ( 29436472) Peak expiratory flow ( 30804560) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 32888494) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Spontaneous preterm birth (preterm delivery) ( 25599974) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 1 diabetes ( 25751624 19430480 18840781) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 22961080 32499647 22158537 30718926 28869590) White blood cell count ( 32888494)
Interacting Genes		90 interacting genes: ANAPC11 APOBEC1 ARID5A BAHD1 BHLHE40 C11orf16 CAMK2A CAMK2G CATSPER1 CCDC120 CCDC187 CCDC24 CDA CELF5 CREB5 CRYAB CYSRT1 DAZAP2 DTX2 EFEMP1 EVX2 FCHO1 GLIS2 GLIS3 GNE GPS2 GRN HELT HEY2 HHEX HOXA1 HOXC8 ITIH6 KPRP KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP26-1 KRTAP3-1 KRTAP4-5 KRTAP6-2 KRTAP6-3 LONRF1 MAGED1 MAPK1IP1L MED25 MEIS2 MGAT5B MYOZ3 NAF1 NOTO NTAQ1 OLIG3 OSR2 OTX1 P4HA3 PATZ1 PDIA2 PITX1 PITX2 PLSCR3 PLSCR4 POU1F1 POU4F2 PRR13 PRR35 RBPMS2 RHOXF2 SMARCC1 SMN1 SMN2 SNRPB TCF7L2 TEKT3 TENT5B TFAP2D TLX3 TNIP1 TOLLIP TRAPPC14 TRIP13 UNC5CL VAC14 VENTX VGLL3 VPS37C ZBTB32 ZC3H10 ZIC1 ZNF414	11 interacting genes: BAG3 CIB1 CLNK ENO1 ITCH KRTAP6-1 NEK6 SUFU TRAF1 TRIB3 TRIP6
Entrez ID		337966	169792
HPRD ID		11218	13582
Ensembl ID		ENSG00000184724	ENSG00000107249
Uniprot IDs		Q3LI64	A0A0S2Z689 Q1PHJ8 Q8NEA6
PDB IDs
Enriched GO Terms of Interacting Partners?
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