HTR2B and SLC44A2

Data Source:
BioGRID (two hybrid)

		HTR2B	SLC44A2
Description		5-hydroxytryptamine receptor 2B	solute carrier family 44 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex	Mitochondrion Lysosomal Membrane Plasma Membrane Membrane Integral Component Of Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding	Choline Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Internalization Heart Morphogenesis Cardiac Muscle Hypertrophy Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Behavior Positive Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Phosphatidylinositol 3-kinase Signaling Intestine Smooth Muscle Contraction Phosphorylation Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Embryonic Morphogenesis Regulation Of Behavior Positive Regulation Of Nitric-oxide Synthase Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Negative Regulation Of Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Temperature Stimulus G Protein-coupled Serotonin Receptor Signaling Pathway	Phosphatidylcholine Biosynthetic Process Choline Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Transmembrane Transport
Pathways		Serotonin receptors G alpha (q) signalling events	Synthesis of PC Transport of bile salts and organic acids, metal ions and amine compounds Neutrophil degranulation
Drugs		Methysergide Cabergoline Zolmitriptan Dihydroergotamine Methylergometrine Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Paroxetine Paroxetine Minaprine Cyclobenzaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Aripiprazole Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic acid diethylamide OPC-28326 Epicept NP-1 PRX-08066 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Esmirtazapine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine
Diseases
GWAS		Proportion of activated microglia (midfrontal cortex) ( 30679421) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Bipolar disorder ( 31043756) Height ( 31562340) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Ischemic stroke ( 29531354) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 24076602) Platelet count ( 29403010 32888494) Platelet distribution width ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Stroke ( 29531354) Thrombosis ( 26908601) Venous thromboembolism ( 25772935 31676865)
Interacting Genes		27 interacting genes: ABCA3 ATP1B1 BNIP3 BNIP3L CBR1 CHPT1 G6PC3 GNA11 GNAQ HAT1 HDGFL2 INSIG1 KIF19 LNX1 MATR3 METRN NAT14 NIPA2 OAZ1 PLLP PPP1R3F RAE1 SLC31A2 SLC37A1 SLC44A2 SNTA1 TRAM1L1	2 interacting genes: BDKRB1 HTR2B
Entrez ID		3357	57153
HPRD ID		03077	16198
Ensembl ID		ENSG00000135914	ENSG00000129353
Uniprot IDs		P41595	A0A088QCU6 Q8IWA5
PDB IDs		4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0
Enriched GO Terms of Interacting Partners?
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