HSPA8 and STUB1

Data Source:
BioGRID (pull down, proximity labelling technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		HSPA8	STUB1
Description		heat shock protein family A (Hsp70) member 8	STIP1 homology and U-box containing protein 1
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GO Annotations	Cellular Component	Prp19 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Lysosome Lysosomal Membrane Late Endosome Autophagosome Cytosol Plasma Membrane Focal Adhesion Membrane Dendrite Secretory Granule Lumen Melanosome Terminal Bouton Lysosomal Lumen Perinuclear Region Of Cytoplasm Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Exosome Blood Microparticle Lumenal Side Of Lysosomal Membrane Photoreceptor Ribbon Synapse Glycinergic Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol Postsynaptic Specialization Membrane Chaperone Complex Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Chaperone Complex
	Molecular Function	G Protein-coupled Receptor Binding Phosphatidylserine Binding RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Clathrin-uncoating ATPase Activity	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Protein Folding Response To Unfolded Protein Neurotransmitter Secretion Cellular Response To Starvation Viral Process Vesicle-mediated Transport Cytokine-mediated Signaling Pathway Regulation Of Protein Stability Cellular Response To Unfolded Protein Protein Refolding Regulation Of Protein-containing Complex Assembly Neutrophil Degranulation Regulation Of MRNA Stability Positive Regulation By Host Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Chaperone Cofactor-dependent Protein Refolding Regulation Of Cell Cycle Membrane Organization Regulation Of Protein Complex Stability Chaperone-mediated Autophagy Late Endosomal Microautophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chaperone-mediated Protein Transport Involved In Chaperone-mediated Autophagy Clathrin Coat Disassembly Regulation Of Postsynapse Organization Regulation Of Cellular Response To Heat Negative Regulation Of Supramolecular Fiber Organization Regulation Of Protein Import Chaperone-mediated Autophagy Translocation Complex Disassembly Slow Axonal Transport	Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Heat ERBB2 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy	Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494) Postoperative acute renal failure after cardiac surgery ( 30678657) Red cell distribution width ( 32888494)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		91 interacting genes: ABI1 AIPL1 ALDOB APOB ATM BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CAPZA1 CAPZB CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DNAJB1 DPP3 DYNLL1 EGFR ENO1 ERBB3 ERH ESR1 FANCC FBP1 GAK GCH1 GOT2 H3C1 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTN3 HTT IL32 JAK2 JUN LALBA LINC01554 MAPK8 MAPT METTL21A NMI NOA1 PHC1 PPID PTEN PTPRF RAF1 RB1 REL RGS2 SGTA SIRPA SP1 SRRT ST13 STAT1 STIP1 STMN1 STUB1 SUMO2 SUMO4 TADA3 TCAP TCERG1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 VHL YWHAG YWHAQ	126 interacting genes: ABL1 ACD AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BCR BMPR1B CASP6 CCL28 CDK4 CDKN1A CFTR CIP2A CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 E2F8 EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A1 GUCY1A2 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 INSR JOSD1 JOSD2 KHDRBS1 LRRK1 LRRK2 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 PA2G4 PFN1 PLK1 POLB POT1 POU5F1 PPARG PPP3CA PRKACA PRKCZ PRKN PRMT1 PRMT5 PSMA3 PSMD4 PTEN RAF1 RGS17 RHBDF2 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TPD52 TRAF6 TXN2 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W VCP XIAP
Entrez ID		3312	10273
HPRD ID		07205	06232
Ensembl ID		ENSG00000109971	ENSG00000103266
Uniprot IDs		P11142 Q53HF2 V9HW22	Q9UNE7
PDB IDs		3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 6B1I 6B1M 6B1N	4KBQ 6EFK 6NSV
Enriched GO Terms of Interacting Partners?
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