HSPA4 and FES

HSPA4

FES

Description heat shock protein family A (Hsp70) member 4 FES proto-oncogene, tyrosine kinase
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Breast cancer ( 29059683)
  • Chronic obstructive pulmonary disease ( 30804561)
  • Diastolic blood pressure ( 30224653)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Eyebrow thickness ( 26926045)
  • HDL cholesterol levels ( 32203549)
  • HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Heel bone mineral density ( 30598549)
  • High density lipoprotein cholesterol levels ( 31928498)
  • High light scatter reticulocyte count ( 32888494)
  • High light scatter reticulocyte percentage of red cells ( 32888494)
  • Mean reticulocyte volume ( 32888494)
  • Mean spheric corpuscular volume ( 32888494)
  • Metabolite levels ( 23823483)
  • Reticulocyte count ( 32888494)
  • Reticulocyte fraction of red cells ( 32888494 27863252)
  • Triglyceride levels ( 32203549 31928498 30698716)
  • Triglyceride levels in current drinkers ( 30698716)
  • Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Birth weight ( 31043758 27680694)
  • Blood pressure ( 21909110)
  • Brain morphology (MOSTest) ( 32665545)
  • Coffee consumption ( 31046077)
  • Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Daytime sleep phenotypes ( 27126917)
  • Diastolic blood pressure ( 27841878 21909115 28739976 27618452)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Hypertension ( 31879980 21909115)
  • Ischemic stroke ( 29531354)
  • Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Medication use (beta blocking agents) ( 31015401)
  • Medication use (calcium channel blockers) ( 31015401)
  • Medication use (diuretics) ( 31015401)
  • Myocardial infarction ( 26343387)
  • Number of sexual partners ( 30643258)
  • Offspring birth weight ( 31043758)
  • Parental lifespan ( 30642433)
  • Pulse pressure ( 27841878 30578418)
  • Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Schizophrenia ( 25056061 29483656 30285260)
  • Stroke ( 29531354)
  • Systolic blood pressure ( 26390057 28135244 27841878 21909115 28739976 27618452 30578418)
  • Systolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes 70 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A 40 interacting genes: APP AR BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR ERBB2 ERBB3 ERBB4 FKBP4 FKBP5 GAB1 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 KIT MDFI MET NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 SMURF1 STAT3 TERF1 TRIM28 ZNF746 ZNF775
Entrez ID 3308 2242
HPRD ID 09025 01814
Ensembl ID ENSG00000170606 ENSG00000182511
Uniprot IDs P34932 A0A024RC92 P07332
PDB IDs 1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93 6JMF
Enriched GO Terms of Interacting Partners?
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