BIRC3 and RIPK3

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		BIRC3	RIPK3
Description		baculoviral IAP repeat containing 3	receptor interacting serine/threonine kinase 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein-containing Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Regulation Of Inflammatory Response Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Cellular Protein Modification Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatase Activity Activation Of Protein Kinase Activity Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus NIK/NF-kappaB Signaling Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Transcription, DNA-templated Regulation Of Activated T Cell Proliferation Protein Autophosphorylation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ligase Activity Positive Regulation Of Oxidoreductase Activity Defense Response To Virus Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Necroptotic Signaling Pathway Execution Phase Of Necroptosis Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1	TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)	Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		41 interacting genes: BCL10 BIRC5 CASP3 CASP7 CASP9 CD40 CYFIP2 DIABLO DZIP3 GLMN GSPT1 HAX1 HTRA2 IKBKE IKBKG MAP3K14 MBTPS1 PACS2 PELI1 RAF1 RCHY1 RIPK1 RIPK2 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 TRAF3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19 YOD1	22 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 UTP11 XIAP ZSCAN20
Entrez ID		330	11035
HPRD ID		03426	09315
Ensembl ID		ENSG00000023445	ENSG00000129465
Uniprot IDs		Q13489	Q9Y572
PDB IDs		2UVL 3EB5 3EB6 3M0A 3M0D	5V7Z 5ZCK
Enriched GO Terms of Interacting Partners?
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