HRC and TRDN

Data Source:
HPRD (in vitro, in vivo)

		HRC	TRDN
Description		histidine rich calcium binding protein	triadin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Z Disc Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen	Endoplasmic Reticulum Cytosol Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen
	Molecular Function	Calcium Ion Binding Protein Binding Ion Channel Binding ATPase Binding	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Ion Channel Binding
	Biological Process	Regulation Of Heart Rate Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Peptidyl-serine Phosphorylation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Heart Contraction Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Relaxation Of Cardiac Muscle Regulation Of Calcium Ion Transmembrane Transport	Cellular Calcium Ion Homeostasis Muscle Contraction Response To Bacterium Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Microtubule Organization Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Heart Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Membrane Potential Endoplasmic Reticulum Membrane Organization Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Cardiac Conduction
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Stimuli-sensing channels Ion homeostasis
Drugs
Diseases
GWAS			Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Borderline personality disorder ( 28632202) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 30591961) Metabolite levels ( 23823483) Nickel levels ( 26025379) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		2 interacting genes: TRDN ZNF699	10 interacting genes: ASPH CALM1 CASQ1 CASQ2 HRC KCNE4 PPIB PTPRN RYR1 SOCS3
Entrez ID		3270	10345
HPRD ID		00818	04474
Ensembl ID		ENSG00000130528	ENSG00000186439
Uniprot IDs		P23327	A0A590UJV0 H9ME53 Q13061 Q8IVK2
PDB IDs
Enriched GO Terms of Interacting Partners?
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