HPRT1 and EEF2KMT

Data Source:
BioGRID (two hybrid)

		HPRT1	EEF2KMT
Description		hypoxanthine phosphoribosyltransferase 1	eukaryotic elongation factor 2 lysine methyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Identical Protein Binding Guanine Phosphoribosyltransferase Activity	Protein Binding Protein-lysine N-methyltransferase Activity
	Biological Process	T Cell Mediated Cytotoxicity Response To Amphetamine Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Purine-containing Compound Salvage Hypoxanthine Salvage Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization	Protein Methylation Peptidyl-lysine Trimethylation
Pathways		Purine salvage	Protein methylation
Drugs		Mercaptopurine 5-O-phosphono-alpha-D-ribofuranosyl diphosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine 3H-pyrazolo[4,3-d]pyrimidin-7-ol 9-Deazaguanine
Diseases		Lesch-Nyhan syndrome; Hypoxanthine-guanine phosophoribosyltransferase deficiency
GWAS		Estimated glomerular filtration rate ( 31015462)
Interacting Genes		10 interacting genes: EEF2KMT EFCAB3 FANCA GNMT ISCU NTAQ1 PRTFDC1 SDCBP SPG21 SREK1IP1	12 interacting genes: HPRT1 IFT88 KIAA1328 LNX1 NR0B1 PICK1 PRKAR1B PRTFDC1 TRIP13 ZNF213 ZNF35 ZNF620
Entrez ID		3251	196483
HPRD ID		02388	18018
Ensembl ID		ENSG00000165704	ENSG00000118894
Uniprot IDs		A0A140VJL3 P00492	K7ES84 Q96G04
PDB IDs		1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6 4RAB 4RAC 4RAD 4RAN 4RAO 4RAQ 5BRN 5BSK 5HIA 5W8V 6BNJ
Enriched GO Terms of Interacting Partners?
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