APCS and FCGR3B

Data Source:
HPRD (in vitro)

		APCS	FCGR3B
Description		amyloid P component, serum	Fc fragment of IgG receptor IIIb
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane Anchored Component Of Membrane Extracellular Exosome
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Carbohydrate Binding Identical Protein Binding Virion Binding Unfolded Protein Binding	Transmembrane Signaling Receptor Activity IgG Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Complement Activation, Classical Pathway Cellular Protein Metabolic Process Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process	Immune Response Cell Surface Receptor Signaling Pathway Neutrophil Degranulation Regulation Of Immune Response
Pathways		Amyloid fiber formation	Post-translational modification: synthesis of GPI-anchored proteins Neutrophil degranulation
Drugs		Zinc Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper Zinc acetate	Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Muromonab Alemtuzumab Alefacept Natalizumab Palivizumab Daclizumab Catumaxomab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576 29875488 28240269) C-reactive protein ( 22939635)	Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576 29875488) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Limited cutaneous systemic scleroderma ( 29293537) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systemic lupus erythematosus ( 26502338) Systemic sclerosis (anti-centromere-positive) ( 29293537) Ulcerative colitis ( 28067908)
Interacting Genes		18 interacting genes: ALX1 C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG	2 interacting genes: APCS IGHG1
Entrez ID		325	2215
HPRD ID		00101	09951
Ensembl ID		ENSG00000132703	ENSG00000162747
Uniprot IDs		P02743 V9HWP0	A0A087WU90 A0A087WZR4 A0A3B3ISU3 O75015
PDB IDs		1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU	1E4J 1E4K 1FNL 1T83 1T89 6EAQ
Enriched GO Terms of Interacting Partners?
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