HOXC8 and HESX1

Data Source:
BioGRID (two hybrid)

		HOXC8	HESX1
Description		homeobox C8	HESX homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Microtubule Cytoskeleton	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Protein N-terminus Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Brain Development Gonad Development Gene Expression Pituitary Gland Development Thyroid Gland Development Otic Vesicle Formation Multicellular Organism Growth Camera-type Eye Development Nose Development Regulation Of Embryonic Development Forebrain Morphogenesis Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Canonical Wnt Signaling Pathway ERK1 And ERK2 Cascade
Pathways
Drugs
Diseases			Septo-optic dysplasia Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256)
Interacting Genes		107 interacting genes: ADAMTSL4 ANKS1A BLZF1 BMPR1A BTG2 C11orf1 C19orf54 C1orf109 CADPS CCM2 CEP70 CRYBA1 CYSRT1 DLX2 DLX5 DVL3 DZIP3 ECM1 FNTB GMNN GOLGA6L9 GSTO2 GYS1 HESX1 HOMEZ HOXD3 HSF2BP IKZF3 JUN KCTD9 KHDC1 KPRP KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-3 KRTAP19-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LDLRAP1 LDOC1 LHX2 LHX3 LRP2BP MAPK8IP2 MEOX1 MEOX2 METTL15 MGAT5B MSX1 NADSYN1 NBPF19 NFKBID NID2 NOTCH2NLA OIP5 PAX5 PAX6 PAX8 PBX1 PBX2 PBX4 PDE4DIP PFDN5 PLA2G10 PLEKHG4 POU2AF1 POU6F2 PPARA PRDM14 PRDM6 RBCK1 RBPMS SLAIN1 SMAD1 SMAD4 SMAD6 SNX17 TBC1D1 TBX19 TBX22 TEKT4 TLE5 TNS2 TRAF1 TRIB3 TRIM27 TRIM42 TRIP6 TSC1 USP54 VENTX WWOX ZFP90 ZMAT5 ZNF34 ZRANB1	12 interacting genes: C1orf109 CATIP GUCD1 HOXC8 KDM1A NCOR1 NPAS2 PRMT6 PROP1 STAT3 TLE1 UBL5
Entrez ID		3224	8820
HPRD ID		00856	03482
Ensembl ID		ENSG00000037965	ENSG00000163666
Uniprot IDs		P31273	A1LQR0 Q9UBX0
PDB IDs			2K40
Enriched GO Terms of Interacting Partners?
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