HMGA1 and DNAJC8

Data Source:
BioGRID (far western blotting)

		HMGA1	DNAJC8
Description		high mobility group AT-hook 1	DnaJ heat shock protein family (Hsp40) member C8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Focal Adhesion Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytosol Intercellular Bridge
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Enzyme Binding Nuclear Receptor Coactivator Activity Structural Constituent Of Chromatin Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding	Protein Binding Hsp70 Protein Binding
	Biological Process	DNA Unwinding Involved In DNA Replication Nucleosome Disassembly Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Chromatin Silencing Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Nuclear Transport Establishment Of Integrated Proviral Latency Oncogene-induced Cell Senescence Positive Regulation Of Cellular Senescence	MRNA Splicing, Via Spliceosome
Pathways		Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF)	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758 27680694) Body mass index ( 26426971 28892062 20935630) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 21998595 20881960 25282103 25429064 19396169 19343178 19893584 23563607 31562340 18391951 20397748 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Monocyte count ( 32888494) Myeloproliferative neoplasms ( 33057200) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Regular attendance at a gym or sports club ( 29970889) Systolic blood pressure ( 30578418) Tonsillectomy ( 27182965 28928442) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Type 2 diabetes (adjusted for BMI) ( 30297969) Uterine fibroids ( 31649266) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Hematocrit ( 32888494)
Interacting Genes		64 interacting genes: ANXA1 ANXA2 APEX1 APP ATF2 CDK1 CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EWSR1 GTF2F2 HEMGN HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HPF1 HSPA1A IRF1 JUN KAT2B METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PARP1 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RCC1 RN7SK RNF4 RXRA SP1 SRF SRPK2 SSB SUFU SYNCRIP UPF2	7 interacting genes: AGTR1 APP FBXO25 HMGA1 IKBKG SRPK1 SRPK2
Entrez ID		3159	22826
HPRD ID		02829	13236
Ensembl ID		ENSG00000137309	ENSG00000126698
Uniprot IDs		P17096 Q5T6U8	O75937
PDB IDs		2EZD 2EZE 2EZF 2EZG
Enriched GO Terms of Interacting Partners?
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