HMGCS2 and HSD17B10

Data Source:
BioGRID (two hybrid)

		HMGCS2	HSD17B10
Description		3-hydroxy-3-methylglutaryl-CoA synthase 2	hydroxysteroid 17-beta dehydrogenase 10
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid
	Molecular Function	Hydroxymethylglutaryl-CoA Synthase Activity Identical Protein Binding	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
	Biological Process	Acetyl-CoA Metabolic Process Cholesterol Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Lipid Metabolic Process Ketone Body Biosynthetic Process	Isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		PPARA activates gene expression Synthesis of Ketone Bodies	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion
Drugs			NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases		HMG-CoA synthase (HMGCS) deficiency	2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Metabolite levels ( 23823483)	Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		3 interacting genes: APP FBXO7 HSD17B10	32 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PRKN PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		3158	3028
HPRD ID		02580	02223
Ensembl ID		ENSG00000134240	ENSG00000072506
Uniprot IDs		A0A140VJL2 P54868	A0A0S2Z410 Q99714
PDB IDs		2WYA	1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?
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