HLA-DRB5 and HLA-DRA

Data Source:
HPRD (in vitro)

		HLA-DRB5	HLA-DRA
Description		major histocompatibility complex, class II, DR beta 5	major histocompatibility complex, class II, DR alpha
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Immunological Synapse Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Peptide Antigen Binding	Protein Binding MHC Class II Protein Complex Binding Polysaccharide Binding MHC Class II Receptor Activity Peptide Antigen Binding T Cell Receptor Binding
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Myeloid Dendritic Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Regulation Of T-helper Cell Differentiation T Cell Receptor Signaling Pathway Cognition Interferon-gamma-mediated Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs		1D09C3 Coccidioides immitis spherule	1D09C3 Coccidioides immitis spherule
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Antinuclear antibody levels ( 25186300) Apolipoprotein A1 levels ( 32203549) Asthma ( 30929738 27182965 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488) Body mass index ( 28892062) Childhood ear infection ( 27182965) Chronic lymphocytic leukemia ( 21131588 26956414) Crohn's disease ( 23850713) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262) Frontotemporal dementia ( 24943344) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Heart rate response to exercise ( 29769521) Hypothyroidism ( 22493691) Immune response to measles vaccine (measles-induced IFN gamma) ( 28289848) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Joint damage in rheumatoid arthritis ( 31596875) Lymphocyte counts ( 32888494) Lymphoma ( 23349640) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Parkinson's disease ( 21292315 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Prostate cancer ( 23535732) Refractive error ( 32231278) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Sarcoidosis (non-Lofgren's syndrome) ( 26651848) SjÃ¶gren's syndrome ( 24097066) Triglyceride levels ( 32203549) Tuberculosis ( 29036319) Type 2 diabetes ( 28869590) Ulcerative colitis ( 28067908 21297633 19122664) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist-to-hip ratio adjusted for body mass index ( 26785701)	Acute-on-chronic liver failure in hepatitis B ( 28130311) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Anti-cyclic Citrullinated Peptide Antibody ( 19287509) Antinuclear antibody levels ( 25186300) Apolipoprotein B levels ( 32203549) Asthma ( 23028483 21804548 30929738 31619474 29273806) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body mass index ( 28892062) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cardiometabolic and hematological traits ( 27668658) Chloride levels ( 29403010) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 23850713) Cystic fibrosis severity ( 21602797) Endometriosis ( 28881265) Eosinophil percentage of white cells ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262) Estimated glomerular filtration rate in diabetes ( 31451708) Feeling worry ( 29500382) Fibrinogen levels ( 28107422) Food antigen IgG levels ( 24962563) Frontotemporal dementia ( 24943344) Giant cell arteritis ( 28041642) Hepatitis B ( 28928442) Hepatitis B vaccine response ( 24282030) HIV-1 viral setpoint ( 26039976) Hodgkin's lymphoma ( 21037568 22286212) Inflammatory bowel disease ( 28008999 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung disease severity in cystic fibrosis ( 26417704) Lymphoma ( 23349640) Multiple sclerosis ( 17660530) Multiple sclerosis (OCB status) ( 23472185) Nodular sclerosis Hodgkin lymphoma ( 29196614) Non-obstructive azoospermia ( 22541561) Obstetric antiphospholipid syndrome ( 28424481) Parkinson's disease ( 20711177) Perceived unattractiveness to mosquitoes ( 28199695) Primary biliary cholangitis ( 28425483 28062665) Primary central nervous system lymphoma ( 31102405) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Sarcoidosis (non-Lofgren's syndrome) ( 26651848) SjÃ¶gren's syndrome ( 24097066 24097067) Staphylococcus aureus infection ( 26450422) Systemic juvenile idiopathic arthritis ( 27927641) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Tuberculosis ( 29036319) Ulcerative colitis ( 28008999 24837172 28067908 23128233 20228798 18836448 21297633 19122664) Urate levels ( 31578528) Vitiligo ( 20410501) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist circumference adjusted for body mass index ( 28552196) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		2 interacting genes: CTAG1B HLA-DRA	11 interacting genes: CD63 CD74 CD82 HLA-DMA HLA-DMB HLA-DRB1 HLA-DRB5 MARCHF1 MBP PRPF40B TLR3
Entrez ID		3127	3122
HPRD ID		09209	00833
Ensembl ID		ENSG00000198502	ENSG00000204287
Uniprot IDs		A0A2Z4LKS3 Q30154	A0A0G2JMH6 P01903
PDB IDs		1FV1 1H15 1HQR 1ZGL	1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1FYT 1H15 1HQR 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 1ZGL 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2Q6W 2SEB 2WBJ 2XN9 3C5J 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4H1L 4H25 4H26 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 5V4M 5V4N 6ATF 6ATI 6ATZ 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6NIX 6QZA 6QZC 6QZD 6R0E
Enriched GO Terms of Interacting Partners?
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