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HCLS1 and CD79A
Data Source:
HPRD
(in vivo)
HCLS1
CD79A
Description
hematopoietic cell-specific Lyn substrate 1
CD79a molecule
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Actin Filament
Plasma Membrane
Site Of Polarized Growth
Cortical Actin Cytoskeleton
Multivesicular Body
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
B Cell Receptor Complex
Membrane Raft
Molecular Function
RNA Polymerase II Transcription Factor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Actin Filament Binding
Transmembrane Signaling Receptor Activity
Protein Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cell Population Proliferation
Response To Hormone
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Actin Filament Polymerization
Erythrocyte Differentiation
Regulation Of Actin Filament Polymerization
Positive Regulation Of Granulocyte Differentiation
Positive Regulation Of Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Cytokine Stimulus
Negative Regulation Of Leukocyte Apoptotic Process
Positive Regulation Of Actin Cytoskeleton Reorganization
Adaptive Immune Response
B Cell Differentiation
B Cell Proliferation
B Cell Activation
B Cell Receptor Signaling Pathway
Pathways
CD22 mediated BCR regulation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
24 interacting genes:
ACTA1
ACTR2
ACTR3
BLZF1
CASP3
CD79A
CSNK2A1
FGR
GRB2
HAX1
HS1BP3
IKBKG
LYN
LZTR1
MAP4K1
QKI
SH2D4A
SH3BP2
SSBP3
SYK
TERF1
TRIM29
WAS
ZBTB25
181 interacting genes:
ADIPOQ
AGTRAP
ALG10
ALG10B
ALG3
APOD
AQP1
AQP3
ATP6V0C
BCL2L2
BET1
BLK
BLNK
BRICD5
BTN2A2
C14orf180
C1GALT1
C2CD2L
C4orf3
CCDC167
CD19
CD5
CD79B
CDIPT
CLDN1
CLN6
CMTM5
CMTM7
CNIH1
CNIH3
COL4A5
CTSA
CTXN3
CYB561
CYB561A3
CYB561D2
CYB5B
DEFB127
DOLK
EDDM3B
EMC6
EMP1
EMP3
FA2H
FAM241B
FANCA
FATE1
FAXDC2
FCAR
FDFT1
FFAR3
FKBP8
FUNDC2
FXYD3
FYN
GALNT15
GIMAP1
GJB1
GPR42
HACD4
HCLS1
HMOX1
HMOX2
IER3
IGHM
INSIG2
ITGAM
JAGN1
JCHAIN
LAMB1
LCK
LEPROTL1
LHFPL5
LPAR3
LTC4S
LYN
MALL
MARCHF2
MFF
MFSD12
MFSD5
MFSD6
MGLL
MMD2
MOSPD3
MS4A13
MYADM
MYADML2
NAT8
NEU1
NINJ2
NIPAL3
NKG7
ORMDL2
OTOP2
PGAP2
PIGR
PKMYT1
PLP2
PLPP6
PLPPR2
PNLIPRP1
PRAF2
PTCH1
PTPN6
REEP6
RHO
RTP2
SACM1L
SEC22B
SERP1
SFTPC
SLC13A4
SLC13A5
SLC16A12
SLC16A13
SLC30A2
SLC35B1
SLC35B4
SLC38A1
SLC39A2
SLC39A9
SLC41A1
SLC41A2
SLC46A3
SLC66A2
SLC6A12
SLC7A1
SMCO4
SMIM3
STRIT1
STX12
STX3
STX8
SYK
SYNJ2BP
TECR
THBD
TM4SF19
TM4SF4
TMBIM6
TMEM107
TMEM11
TMEM128
TMEM140
TMEM147
TMEM14B
TMEM176A
TMEM187
TMEM19
TMEM218
TMEM222
TMEM229B
TMEM239
TMEM243
TMEM254
TMEM262
TMEM42
TMEM86A
TMEM86B
TMPPE
TNFRSF10C
TRAM1L1
TRARG1
TSNARE1
TSPAN2
TSPO2
UBE2J1
UBIAD1
UNC93B1
VAMP3
VAPA
VAPB
VTI1B
WFDC2
WFS1
YIF1A
YIPF4
YIPF6
ZDHHC15
ZDHHC22
Entrez ID
3059
973
HPRD ID
03199
00203
Ensembl ID
ENSG00000180353
ENSG00000105369
Uniprot IDs
P14317
P11912
PDB IDs
1CV9
Enriched GO Terms of Interacting Partners
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