H1-2 and WDR12

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		H1-2	WDR12
Description		H1.2 linker histone, cluster member	WD repeat domain 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Euchromatin Nucleus	Nucleoplasm Nucleolus Preribosome, Large Subunit Precursor PeBoW Complex
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Notch Signaling Pathway Ribosomal Large Subunit Biogenesis Regulation Of Cell Cycle
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Ischemic stroke (small-vessel) ( 29531354) Myocardial infarction (early onset) ( 19198609) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547) White matter integrity (fractional anisotropy) ( 32358547)
Interacting Genes		30 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 SNCA VHL WDR12 WDR5 YBX1	2 interacting genes: H1-2 NOTCH1
Entrez ID		3006	55759
HPRD ID		07514	18295
Ensembl ID		ENSG00000187837	ENSG00000138442
Uniprot IDs		P16403	Q53T99 Q9GZL7
PDB IDs			6N31 6P0Q
Enriched GO Terms of Interacting Partners?
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