SH3KBP1 and ARHGAP27

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SH3KBP1	ARHGAP27
Description		SH3 domain containing kinase binding protein 1	Rho GTPase activating protein 27
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse	Cytoplasm Membrane
	Molecular Function	Protein Binding SH3 Domain Binding	GTPase Activator Activity SH3 Domain Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization	Receptor-mediated Endocytosis Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Rho GTPase cycle
Drugs
Diseases
GWAS		Platelet count ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical surface area (global PC1) ( 32198502) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Hemoglobin levels ( 32327693) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Parkinson's disease ( 28892059) Refractive error ( 32231278) Systemic lupus erythematosus ( 29848360)
Interacting Genes		58 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BHLHB9 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A GGN GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	3 interacting genes: CDC42 RAC1 SH3KBP1
Entrez ID		30011	201176
HPRD ID		02301	12477
Ensembl ID		ENSG00000147010	ENSG00000159314
Uniprot IDs		B7Z6E8 Q5JPT6 Q96B97	E9PIR1 E9PNT2 Q6ZUM4 Q8N2Y9
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	3PP2
Enriched GO Terms of Interacting Partners?
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