LMCD1 and NKX3-1

Data Source:
BioGRID (two hybrid)

		LMCD1	NKX3-1
Description		LIM and cysteine rich domains 1	NK3 homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm Cytosol Site Of DNA Damage
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Estrogen Receptor Activity Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Self-association MADS Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cardiac Muscle Hypertrophy Cellular Protein Metabolic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade	Metanephros Development Somitogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organism Development Salivary Gland Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Differentiation Androgen Receptor Signaling Pathway Regulation Of Protein Localization Response To Testosterone Cellular Response To Drug Dorsal Aorta Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cell Division Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Mitotic Cell Cycle Arrest Negative Regulation Of Estrogen Receptor Binding Positive Regulation Of Androgen Secretion Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Surfactant metabolism
Drugs
Diseases			Prostate cancer
GWAS		Brain volume in infants (intracranial brain volume) ( 28763065) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Low high density lipoprotein cholesterol levels ( 26879886) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Platelet count ( 32888494) Plateletcrit ( 32888494) Rumination (response to stress) ( 30886212) Uterine fibroid number (single vs multiple) ( 30196971)	Birth weight ( 31043758) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Prostate cancer ( 32986714 26443449) Prostate-specific antigen levels ( 28139693) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: APP FBXO25 IKBKG NKX3-1 PRKAG3 RABIF TEKT4 TRIM55 TRIM63	37 interacting genes: AEN CCT7 CD200R1L CENPX CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 MT-ND4 PEBP1 PTMS RABL6 RARG RHOXF2 RNF4 RPL37A RPSA SLC22A18 SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 TEX264 TOPORS TPT1 WDR77 ZNF417
Entrez ID		29995	4824
HPRD ID		06891	03620
Ensembl ID		ENSG00000071282	ENSG00000167034
Uniprot IDs		B4DEY6 B7Z6R5 H7C3D2 Q9NZU5	Q99801
PDB IDs			2L9R
Enriched GO Terms of Interacting Partners?
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