UBQLN1 and CHRNA3

Data Source:
HPRD (in vivo, two hybrid)

		UBQLN1	CHRNA3
Description		ubiquilin 1	cholinergic receptor nicotinic alpha 3 subunit
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Aggresome Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Postsynaptic Density Integral Component Of Membrane Dendrite Neuron Projection Neuronal Cell Body Plasma Membrane Raft Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Macroautophagy Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Aggrephagy Cellular Response To Hypoxia Autophagosome Maturation Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process	Ion Transport Regulation Of Smooth Muscle Contraction Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Locomotory Behavior Regulation Of Acetylcholine Secretion, Neurotransmission Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Membrane Potential Regulation Of Dendrite Morphogenesis Nervous System Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Acetylcholine Receptor Signaling Pathway Response To Acetylcholine
Pathways		Cargo recognition for clathrin-mediated endocytosis	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs			Nicotine Butabarbital Methadone Fluoxetine Dextromethorphan Levamisole Ethanol Amantadine Pentolinium Bupropion Levacetylmethadol Gantacurium Epibatidine Cytisine
Diseases
GWAS		Metabolite levels ( 23823483) Refractive error ( 32231278)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 22080838 30804561 19300482 25101718 20173748) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Dentures ( 31235808) Diffusing capacity of carbon monoxide ( 30694715) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Exhaled carbon monoxide levels ( 25072098) Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Familial lung cancer ( 29924316) Local histogram emphysema pattern ( 25006744) Lung adenocarcinoma ( 19836008) Lung cancer ( 18385676 18385738 19654303 18780872 30104567) Lung cancer in ever smokers ( 30104567) Lung function (FEV1/FVC) ( 31453325) Lung function (FEV1/FVC) variance ( 31453325) Nicotine dependence ( 18385739 26440539) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity-related traits ( 23251661) Parental lifespan ( 30642433 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 31285632) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Serum albumin level ( 23022100) Smoking behavior ( 20418889 20418890) Smoking behaviour (cigarettes smoked per day) ( 31089300 30617275) Smoking status (heavy vs light) ( 28520984) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		233 interacting genes: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 ANOS1 APOC2 APOC4 APP ASCL1 ATXN3 BAG6 BPIFA1 C1QA C1QTNF2 C1QTNF4 CALU CCL3 CCL7 CD47 CD99 CD99L2 CDIP1 CDSN CHGB CHRNA3 CHRNA4 CHRNB4 CLCN2 COL10A1 COL1A2 COL9A2 COLGALT2 COMTD1 COPS4 CSN3 CSTF2 CSTF2T CTAG1A CTAG1B CTAG2 CYB5R1 DAZAP2 DEFA6 DEFB115 DESI1 DEXI DMKN DNAJB2 DOLK ECM1 EFEMP2 EP300 EPS15 ERP27 ERP29 ETNK1 F8 FAM163B FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FOLR3 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GAL GHRL GIT2 GKAP1 GPR162 GPX3 GRM2 GUCA2A GUCA2B GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IER3IP1 IGFBP6 IGL IGLC1 IGLV2-14 IL6ST IRF1-AS1 IST1 ITPRIPL1 JPH4 JSRP1 KLHL42 LAIR2 LAMB1 LCN2 LHX4 LITAF LNPEP MANBAL MAP3K1 MCM7 MDK MESD MICOS10-NBL1 MIEF1 MIEF2 MLLT6 MTNR1A MTOR MYDGF NAXD NBL1 NDE1 NDOR1 NEDD8 NGLY1 NLGN3 NME3 NPPA NPY NT5C3A NUP58 NXF1 OST4 P4HB PARVA PBXIP1 PCDH18 PCDHA4 PIAS2 PIK3IP1 PLAAT1 PLAAT2 PLAAT3 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PRR4 PSEN1 PSEN2 PSMD4 PSMD6 PSORS1C2 PTN RAI2 RARA RASSF5 RIC8A RNF144B RNF208 RNF4 RPN1 RPS27A RSRC2 RTL8A RTL8B RTL8C SCG2 SCG5 SCMH1 SERPINE1 SERPINI2 SEZ6L SIL1 SLC16A3 SLC29A2 SLPI SMAD9 SMIM19 SMIM2 SMR3B SMURF1 SOD3 SPAG8 SPARC SRGN STAM2 STMN3 SYNJ2BP TARDBP TFF1 TICAM1 TLR4 TMCO6 TMEM258 TMEM31 TMEM37 TMEM67 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM23 TRIM32 TXNDC12 UBA52 UBB UBC UBE2I UBE2V1 UBE3A UBQLN2 UBQLN4 UBXN1 UBXN4 UBXN7 VWC2 WBP2 WFDC12 XPO4 ZBTB8B ZFAND2B ZG16 ZG16B ZMYM5 ZNF343	2 interacting genes: CHRNB4 UBQLN1
Entrez ID		29979	1136
HPRD ID		05440	07511
Ensembl ID		ENSG00000135018	ENSG00000080644
Uniprot IDs		A0A024R258 Q9UMX0	P32297
PDB IDs		2JY5 2JY6 2KLC	4ZK4 5SYO 5TVC 6PV7 6PV8
Enriched GO Terms of Interacting Partners?
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